AOD-9604
A small piece of the growth hormone molecule, studied for the part of that hormone linked to breaking down stored fat.
Learn about AOD-9604Performance & body composition
IGF-1 LR3
Also known as: Insulin-like growth factor 1 LR3
A changed version of a natural growth factor, built to stay active longer than the form the body makes on its own.
- Class
- Modified growth factor
- Type
- IGF-1 analog
- Category
- Performance & body composition
- FDA status
- Not FDA-approved
Overview
What it is
IGF-1 LR3 is a lab-made version of insulin-like growth factor 1, a hormone the liver releases in response to growth hormone. The LR3 change keeps it active in the body much longer than the natural form.
IGF-1 is the hormone that carries out most of what growth hormone is credited with. The liver releases it in response to growth hormone, and it does the actual work on muscle and tissue.
A form of IGF-1 is FDA-approved as a medicine, but only for children with a rare growth disorder. IGF-1 LR3 is a different, modified molecule and is not approved for anything.
The LR3 change was designed for laboratory use, to keep cells exposed to the growth factor for longer. That same change is why it lasts so long in the body.
Benefits
What it supports
- Supports muscle-building signals and protein synthesis during training
- Supports body-composition goals tied to how the body uses fat
- Supports how the body routes nutrients toward recovery
- Acts directly on the growth factor pathway rather than prompting the body to make more
Mechanism
How it works
1
Most IGF-1 in your blood is not free. It rides bound to carrier proteins, which control how much reaches tissue and when.
2
The LR3 modification stops it from binding those carriers. Without that brake, far more stays active, and it stays active much longer than the natural form.
3
IGF-1 tells muscle cells to build protein and influences how the body routes nutrients between muscle and fat.
4
Removing the brake is the whole point and also the whole risk. Growth signals are meant to be regulated, and this version bypasses much of that regulation.
Context
Who it's for
Adults focused on muscle-building signals during hard training
People trying to understand how growth factors differ from growth hormone releasers
Adults comparing direct growth factor approaches with releasers like tesamorelin
People researching performance compounds who want the risks laid out
Landscape
In the landscape
How this compound compares to related options in the wellness landscape.
- AOD-9604
A fragment of growth hormone aimed at fat, not a growth factor. Different class and different goal.
- Tesamorelin
Prompts your own body to release growth hormone, which then raises IGF-1 naturally. This acts directly instead.
In this area
Related therapies
Other compounds that support overlapping wellness goals.
Questions
IGF-1 LR3 FAQ
Good to know
Regulatory & considerations
IGF-1 LR3 is not FDA-approved. That means the FDA has not reviewed it for safety or effectiveness for the uses described here. It is also banned by anti-doping organizations, so athletes in tested sport should know it can trigger a positive test.
Peptides in our shop are sourced from US-licensed manufacturers.
IGF-1 LR3 is not FDA-approved, and it is banned by anti-doping organizations.
It can drop blood sugar sharply, because it acts partly like insulin. That reaction can be serious and comes on fast.
IGF-1 promotes cell growth broadly. Anyone with a personal or family history of cancer should raise that before the conversation goes any further.
Because it bypasses the carrier proteins that normally regulate it, effects are harder to predict than with the natural form.
Shop IGF-1 LR3
See current pricing and availability for IGF-1 LR3 in our shop. If a medical evaluation is needed, a licensed provider guides you through it.
Individual results vary. General information on this site is not a substitute for professional medical advice.