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Intrinsic Longevity
Wellness & vitality

CJC-1295 (with DAC)

A longer-acting copy of the brain signal for growth hormone, changed so it sticks to a blood protein and stays active for days.

Class
Growth hormone releaser
Modification
Drug affinity complex
Duration
Long-acting
FDA status
Not FDA-approved
Shop CJC-1295 (with DAC)
Overview

What it is

CJC-1295 with DAC is a lab-made copy of growth hormone-releasing hormone. DAC stands for drug affinity complex, an added piece that lets the peptide attach to albumin, a protein in blood, so it lasts much longer.

The DAC modification was the point of this version. Adding it lets the peptide latch onto albumin, the most common protein in blood, which stretches its working life from hours to days.

It was studied in early human trials in the 2000s, where it did raise growth hormone and IGF-1 for extended periods. Development did not continue to approval.

It sits in the same corner as tesamorelin, which copies the same brain signal but reached approval for a specific condition.

Benefits

What it supports

  • Supports lean muscle and recovery through a steadier growth hormone signal
  • Supports body-composition goals without the short pulses of the without-DAC form
  • Supports sleep quality, energy, and daily vitality goals
  • Offers a longer-lasting option for people comparing the two CJC-1295 forms
Mechanism

How it works

1

It binds the same pituitary receptors as the brain's own growth hormone signal, prompting the gland to release growth hormone.

2

The DAC piece then attaches it to albumin in the blood. Albumin circulates for weeks, so the peptide rides along instead of being cleared quickly.

3

The result is a steadier, longer signal rather than short bursts. Growth hormone and IGF-1 stay elevated for days at a time.

4

That steadiness is the trade-off worth understanding. It is convenient, but it moves further from the natural on-and-off rhythm the body uses.

Context

Who it's for

Adults who prefer a longer-lasting signal over frequent short pulses

People comparing the two CJC-1295 forms and trying to understand the difference

Adults focused on lean muscle, recovery, and body composition

People weighing this against tesamorelin, which is approved for one specific condition

Landscape

In the landscape

How this compound compares to related options in the wellness landscape.

  • CJC-1295 (without DAC)

    The short-acting version, which clears within hours and keeps a more pulse-like pattern.

  • Tesamorelin

    Copies the same brain signal and is FDA-approved for one specific condition. Approval is the main difference.

In this area

Related therapies

Other compounds that support overlapping wellness goals.

Questions

CJC-1295 (with DAC) FAQ

Good to know

Regulatory & considerations

CJC-1295 with DAC is not FDA-approved. That means the FDA has not reviewed it for safety or effectiveness for the uses described here. Published human data is limited to small early studies.

Peptides in our shop are sourced from US-licensed manufacturers.

CJC-1295 with DAC is not FDA-approved, and its status under pharmacy compounding rules is still being decided.

A long-acting signal keeps growth hormone elevated for days, which moves further from the body's natural rhythm than short pulses do.

Raising growth hormone can affect blood sugar and can cause fluid retention or joint aches.

Shop CJC-1295 (with DAC)

See current pricing and availability for CJC-1295 (with DAC) in our shop. If a medical evaluation is needed, a licensed provider guides you through it.

Shop CJC-1295 (with DAC)

Individual results vary. General information on this site is not a substitute for professional medical advice.